Multiresistant Shigella infections caused by organisms carrying R plasmids coding for antibiotic resistance are becoming more common. Resistance genes can move in vivo between enteric flora and enteric pathogens and within the environment mainly through drinking water. In part I of this study, most of the isolated Shigella strains were multiantibiotic resistant [MAR]. Hence, this part aimed at studying the antibiotic resistance pattern of the gut & drinking water E.coli. Stool samples from 205 primary school children [the same of part 1] were cultured for isolation of gut E. coli. Drinking water samples from household taps, public taps &storage pots [zeer ] were collected and examined for the presence of E. coli using the standard membrane filter technique. All the isolated E.coli were tested for their susceptibility to the following antibiotics: ampicillin, sulfamethoxazole- trimethoprim, gentamicin, chloramphenicol, tetracycline, nalidixic acid, nitrofurantoin, ceftriaxone & ciprofloxacin. Out of the stool isolated E.coli, 78.5% were MAR. E.coli was isolated from 61.3% of the stored zeer water of which the majority [71.1%] were MAR. The resistance was high to the community- used antibiotics while the hospital- used agents still retained their efficacy .In conclusion, resistant enteric flora might be a reservoir of the dissemination of resistance plasmids to the pathogenic enteric bacteria. In addition, the environmental routes [mainly drinking water] play a major role in the epidemiology and spread of MAR enteric pathogens.