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238819

Alterations in Enzymes Modulating Antioxidant Balance and Oxidative Stress Indices in the Aged Rats

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Last updated: 03 Jan 2025

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Abstract

Age related changes in antioxidant enzyme levels and free radical indices were investigated in brain, heart, kidney, lung and liver tissues of adults and aged rats. Activities of superoxide dismutase [SOD] were significantly higher in all organs of aged rats except the liver. On the other hand, glutathione peroxidase [GSH-Px] activity levels were significantly higher in kidney and heart tissues only but lower in liver of old rats. However, catalase [CAT] activities were significantly lower in brains and livers and higher in lungs of the aged group. We found concomitant increases in lipid peroxides as well as oxidized glutathione in brain and liver tissues of aged rats. These data suggest that the increase of some protective enzymes could have an important role in preserving tissues from toxic effect of superoxide anion and hydrogen peroxide while decreases of other protective enzymes may be responsible for free radical damage or they may be inactivated by free radical molecules which increase with age.

DOI

10.21608/jhiph.2001.238819

Keywords

Alterations, Enzymes, Antioxidant Balance, Oxidative Stress, Aged Rats

Authors

First Name

Amal

Last Name

Soliman

MiddleName

S.M

Affiliation

Department of Biochemistry, Medical Research Institute, Alexandria University, Egypt

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Orcid

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First Name

Azza

Last Name

Abdou

MiddleName

S.

Affiliation

Department of Physiology, Medical Research Institute, Alexandria University, Egypt

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Orcid

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Volume

31

Article Issue

1

Related Issue

34155

Issue Date

2001-01-01

Receive Date

2022-05-23

Publish Date

2001-01-01

Page Start

47

Page End

56

Print ISSN

2357-0601

Online ISSN

2357-061X

Link

https://jhiphalexu.journals.ekb.eg/article_238819.html

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https://jhiphalexu.journals.ekb.eg/service?article_code=238819

Order

5

Type

Original Article

Type Code

511

Publication Type

Journal

Publication Title

Journal of High Institute of Public Health

Publication Link

https://jhiphalexu.journals.ekb.eg/

MainTitle

Alterations in Enzymes Modulating Antioxidant Balance and Oxidative Stress Indices in the Aged Rats

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Article

Created At

22 Jan 2023