Patients exposed to sever trauma, go into pathophysiological state that threaten the integrity of internal homeostasis, causing alteration in the sympathoadrenal function. The aim of work was to study some of the hormonal changed in patients with major injuries, and to study the correlation between the level of the Hormones and the severity of trauma. The study was conducted on 20 patients with multitrauma, with injury severity score more than 14, in addition to 10 control (normal persons). The separated plasma was analysed for adrenaline, nor adrenaline, cortisol, growth Hormone, thyroxine (T₄) and tri-iodothyronine (T₃) levels. There were significant elevation of plasma adrenaline, noradrenaline and cortisol in all patients. Growth hormone level was elevated in the low risk group patients. There was significant decrease in plasma T₃ and T₄ in all patients. T₃ and cortisol can be taken in the first day in patients with major injuries to predict their prognosis and identify the efficacy of medical care. Growth hormone and thyroid hormone replacement may be of value in trauma patients. Other endocrinal changes need to be evaluated in future studies to predict their validity as a prognostic parameter in trauma patient.