Beta
212225

Premarital Genetic Investigations: An Attempt To Reduce Genetic Disorders

Article

Last updated: 03 Jan 2025

Subjects

-

Tags

-

Abstract

Genetic disorders represent a major health problem in the world. Major efforts directed towards lightening the burden of these disorders on patients, family, future generations and on the community at large. A total of 194 couples (future husbands and wives] were referred to the outpatient genetic clinic, Medical Research Institute, University of Alexandria for premarital genetic investigations. About 64.6 % had a family history of various genetic disorders. Consanguinity was found among 85.6 % of couples. Abnormal result of premarital investigations was found in 17% of couples. Twenty six couples were at risk of having abnormal outcome due to a disorder in one or both partners. These included 7 with chromosomal abnormalities [ two mosaic Turner syndrome, one Klinefelter syndrome, one pericentric inversion of chromosome 9, one balanced translocation carrier, one fragile X carrier and one had chromosomal breaks], 5 couples had B- thalassemia minor, one had sickle cell / B thalassemia, one had hemophilia, 3 female partners had diabetes mellitus, 2 female partners were Rh -ve, 2 male partners had epilepsy, 1 female had breast cancer, 1 male had syphilis, 1 female had toxoplasmosis, 1 male had hepatitis C virus and 1 male with familial hypercholesterolemia. Premarital genetic investigations are important tools in the detection of genetic diseases as well as the reduction of their incidence.

DOI

10.21608/jhiph.2002.212225

Keywords

premarital, Genetic Investigations

Authors

First Name

Amal

Last Name

Abd El Aziz

MiddleName

M.

Affiliation

Human Genetics Department, Medical Research Institute, Alexandria University, Egypt

Email

-

City

-

Orcid

-

First Name

Mohamed

Last Name

Mokhtar

MiddleName

M.

Affiliation

Human Genetics Department, Medical Research Institute, Alexandria University, Egypt

Email

-

City

-

Orcid

-

First Name

Amal

Last Name

Behery

MiddleName

K.

Affiliation

Human Genetics Department, Medical Research Institute, Alexandria University, Egypt

Email

-

City

-

Orcid

-

First Name

Nargues

Last Name

Hasanein

MiddleName

M.

Affiliation

Human Genetics Department, Medical Research Institute, Alexandria University, Egypt

Email

-

City

-

Orcid

-

Volume

32

Article Issue

3

Related Issue

29405

Issue Date

2002-07-01

Receive Date

2022-01-02

Publish Date

2002-07-01

Page Start

651

Page End

664

Print ISSN

2357-0601

Online ISSN

2357-061X

Link

https://jhiphalexu.journals.ekb.eg/article_212225.html

Detail API

https://jhiphalexu.journals.ekb.eg/service?article_code=212225

Order

16

Type

Original Article

Type Code

511

Publication Type

Journal

Publication Title

Journal of High Institute of Public Health

Publication Link

https://jhiphalexu.journals.ekb.eg/

MainTitle

Premarital Genetic Investigations: An Attempt To Reduce Genetic Disorders

Details

Type

Article

Created At

22 Jan 2023