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Pulmonary Dysfunction in Silica-Exposed Workers: A Relationship to Oxidant/Antioxidant State and Soluble Interleukin-2 Receptors

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Last updated: 03 Jan 2025

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Abstract

Silicosis is a chronic progressive granulomatous and fibrotic lung disease caused by inhalation of quartz [SiO2] that leads to the formation of complex substances containing phosphosilicate with a single oxygen atom which is highly catalytic and reactive. Twenty male workers exposed to silica and 11 control subjects were studied in a trial to clarify the role of oxidant/antioxidant state, soluble interleukin 2 receptors in relation to pulmonary performance. A restrictive ventilatory impairment was detected in the present study as assessed by significant decrease in flow rates [FVC, FEV., FEV, , FVC%, FEF25%-75% and MVV] and in VE and VA values compared to their respective values of controls, P< 0.05. Significant negative correlations were observed between duration of exposure to silica and FVC, FEV,1: FEF25%-75% [r= -0.857, -0.695 and -0.582 respectively, P = 0.001].The oxidant/ antioxidant balance of silicotic cases was disturbed as shown by significant high levels of oxidants [Lipid peroxides] P = 0.001 and significant low levels of antioxidant enzymes [superoxide dismutase and catalase], P < 0.05. The antioxidant vitamins [A,C and E] were as well significantly decreased compared to those of controls, P < 0.01. We observed positive correlations between FVC and plasma levels of vitamin C and E [r= 0.878 and 0.915, P = 0.001]. Serum soluble interleukin-2 receptors [sIL-2r] were elevated in patient's serum indicating that activation of T-lymphocytes might have a role in initiating and sustaining symptoms in patients with silicosis. These data suggest that exposure to silica causes increase oxidant burden which could lead to imbalance of the oxidant/ antioxidant state ending with enhanced pulmonary injury and fibrosis. Abbreviations: FVC: Forced vital capacity FEV1 :Forced expiratory volume in one second. FEF25%-75%* MVV: Maximum voluntary ventilation VE: Minute ventilation VA: Alveolar ventilation :Maximum mid expiratory flow rate

DOI

10.21608/jhiph.2002.212220

Keywords

Pulmonary Dysfunction, Silica-Exposed Workers, Oxidant/Antioxidant State, Soluble Interleukin-2 Receptors

Authors

First Name

Maha

Last Name

Ibrahim

MiddleName

S.

Affiliation

Department of Physiology, Medical Research Institute, Alexandria University, Egypt

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Orcid

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First Name

Sally

Last Name

Gabbour

MiddleName

N.

Affiliation

Department of Physiology, Medical Research Institute, Alexandria University, Egypt

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City

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Orcid

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First Name

Mervat

Last Name

El Seweify

MiddleName

E.

Affiliation

Department of Physiology, Medical Research Institute, Alexandria University, Egypt

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City

-

Orcid

-

First Name

Iman

Last Name

Sharaf

MiddleName

A.

Affiliation

Department of Biochemistry , Medical Research Institute, Alexandria University, Egypt

Email

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City

-

Orcid

-

First Name

Mona

Last Name

El Sayed

MiddleName

H.

Affiliation

Department of Immunology, Medical Research Institute, Alexandria University, Egypt

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Volume

32

Article Issue

3

Related Issue

29405

Issue Date

2002-07-01

Receive Date

2022-01-02

Publish Date

2002-07-01

Page Start

633

Page End

650

Print ISSN

2357-0601

Online ISSN

2357-061X

Link

https://jhiphalexu.journals.ekb.eg/article_212220.html

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https://jhiphalexu.journals.ekb.eg/service?article_code=212220

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15

Type

Original Article

Type Code

511

Publication Type

Journal

Publication Title

Journal of High Institute of Public Health

Publication Link

https://jhiphalexu.journals.ekb.eg/

MainTitle

Pulmonary Dysfunction in Silica-Exposed Workers: A Relationship to Oxidant/Antioxidant State and Soluble Interleukin-2 Receptors

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Article

Created At

22 Jan 2023