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208918

Expression of Lymphocyte Homing Associated Cell Adhesion Molecule [H-CAM, CD44] in B-Lineage Neoplasms

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Last updated: 22 Jan 2023

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Abstract

Adhesion molecules [AM], such as C44 and its variant isoforms, are known to play a pivotal role in cell-cell and dell-stroma interactions involved in proliferation, spread via blood and lymph vessels, tumor invasion and metastasis. This work was aiming to study the a expression of CD44 adhesion molecule in different B lineage-cell neoplasms in order to understand and predict the biologic behavior and heterogeneity of these disorders. The study included thirty patients with:B lineage neoplasms, eleven with acute lymphoblastic leukemia, nine with chronic lymphocytic leukemia, one patient with hairy cell leukemia and nine with lymphoma. They were 21 males and 9 females. Their ages ranged between 3-73 years. Ten healthy individuals are included as control group. Immunophenotyping on peripheral blood [PB] or bone marrow [BM] samples using a panel of monoclonal antibodies to select patients with clonal B lymphocytes neoplasms as well as expression of CD44, using either PB or BM mononuclear cells, were performed by flow cytometry. A significant relation between CD44% and its mean fluorescent intensity [MFI] was observed in ALL, CLL versus the control group, negative correlation was found between blast % in PB as well as TLC and CD44% in ALL group. Negative correlation between CD44% and platelet count and positive correlation between MFI and lymphnode enlargement were observed in lymphoma group. Significant difference between CD44% in low grade and high grade lymphomas versus CLL was noticed. Also a significant difference was found in MFI on comparing low grade and high grade lymphomas versus CLL and highly significant results were found between intermediate grade and CLL. In summary, the data presented in this study may help to clarify the qualitative abnormalities of CD44 expression by neoplastic B-lymphocyte and confirm that specific patterns may be of value to refine the diagnosis of B-cell lymphoproliferative disorders.

DOI

10.21608/jhiph.2002.208918

Keywords

Lymphocyte Homing, Cell Adhesion Molecule, [H-CAM, CD44], B-Lineage Neoplasms

Authors

First Name

Maged

Last Name

Mikhail

MiddleName

M.

Affiliation

Clinical Pathology Department, Faculty of Medicine, Alexandria University, Egypt

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City

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Orcid

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First Name

Magda

Last Name

Sultan

MiddleName

M.

Affiliation

Hematology Department, Medical Research Institute, Alexandria University, Egypt

Email

-

City

-

Orcid

-

First Name

Nahla

Last Name

Farahat

MiddleName

MG.

Affiliation

Clinical Pathology Department, Faculty of Medicine, Alexandria University, Egypt

Email

-

City

-

Orcid

-

First Name

Oulvia

Last Name

El Rakshy

MiddleName

S.

Affiliation

Hematology Department, Medical Research Institute, Alexandria University, Egypt

Email

-

City

-

Orcid

-

First Name

Nadia

Last Name

Sadek

MiddleName

A.

Affiliation

Hematology Department, Medical Research Institute, Alexandria University, Egypt

Email

-

City

-

Orcid

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First Name

Naglaa

Last Name

Elmongui

MiddleName

GM.

Affiliation

Hematology Department, Medical Research Institute, Alexandria University, Egypt

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City

-

Orcid

-

Volume

32

Article Issue

3

Related Issue

29405

Issue Date

2002-07-01

Receive Date

2021-12-12

Publish Date

2002-07-01

Page Start

431

Page End

442

Print ISSN

2357-0601

Online ISSN

2357-061X

Link

https://jhiphalexu.journals.ekb.eg/article_208918.html

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https://jhiphalexu.journals.ekb.eg/service?article_code=208918

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2

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Original Article

Type Code

511

Publication Type

Journal

Publication Title

Journal of High Institute of Public Health

Publication Link

https://jhiphalexu.journals.ekb.eg/

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Article

Created At

22 Jan 2023