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200287

Immune Dysregulation Associated with Breast Cancer

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Last updated: 22 Jan 2023

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Abstract

ICancer development depends not only on the tumor cells themselves, but also on the immune regulatory effects of various cells. In an attempt to further understand the prognostic significance of p53, apoptosis and sIL-2R in cancer breast, we have evaluated serum levels of p53 and sIL-2R in 15 breast cancer patients by enzyme linked immunoassay. While DNA fragmentation was assessed as a marker of apoptosis using photometric sandwich ELISA technique together with 10 healthy women as control. A significant increase in serum p53 [8.18±0.4u/ml] and apoptosis [1.56±0.32 u/ml] were recorded in cancer patients than in control [6.29±0.38 u/ml] and [0.114±0.009 u/ml] respectively. This increase was positively correlated with the stage of carcinoma. A significant increase in serum sIL-2R was also observed in patients [1156.74±176.27 u/ml] than in control subject [774.145±40.641 u/ml]. Our results revealed the presence of immune dysregulation in patients with breast cancer, and we suggest that serum sIL-2R level; p53 and apoptosis could be useful markers to identifying population of patients with poor prognosis and follow up the response to chemotherapy.

DOI

10.21608/jhiph.2003.200287

Keywords

Immune Dysregulation, breast cancer

Authors

First Name

Mona

Last Name

El-Sayed

MiddleName

H.

Affiliation

Department of Immunology, Medical Research Institute, Alexandria University, Egypt

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Orcid

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First Name

Inas

Last Name

Aly

MiddleName

M.

Affiliation

Department of Oncology, Medical Research Institute, Alexandria University, Egypt

Email

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City

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Orcid

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First Name

Salwa

Last Name

Abou Rawash

MiddleName

N.

Affiliation

Department of Oncology, Medical Research Institute, Alexandria University, Egypt

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Orcid

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Volume

33

Article Issue

1

Related Issue

27973

Issue Date

2003-01-01

Receive Date

2021-10-19

Publish Date

2003-01-01

Page Start

129

Page End

140

Print ISSN

2357-0601

Online ISSN

2357-061X

Link

https://jhiphalexu.journals.ekb.eg/article_200287.html

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https://jhiphalexu.journals.ekb.eg/service?article_code=200287

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Original Article

Type Code

511

Publication Type

Journal

Publication Title

Journal of High Institute of Public Health

Publication Link

https://jhiphalexu.journals.ekb.eg/

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Article

Created At

22 Jan 2023