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199892

Study of Cytogenetic Biomarkers in Human Fascioliasis and Triclabendazole Treatment

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Last updated: 03 Jan 2025

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Abstract

The cytogenetic effect of triclabendazole an antihelminthic drug used for the treatment of human fascioliasis was evaluated in peripheral blood lymphocytes of 30 patients with fasciola hepatica before and after treatment with the drug. The number of cells with chromosomal aberrations and sister chromatid exchanges did not show any statistically significant differences in the patients either before treatment when compared to the control or after triclabendazole therapy [P2 0.05). Based on the results of the present study, our data indicate that infection with fasciola hepatica does not increase chromosomal aberrations or sister chromatid exchanges, and that the genotoxic effect of triclabendazole indicate that the drug is not a mutagenic agent and could be used safely in therapeutic doses for the treatment of human fascioliasis.

DOI

10.21608/jhiph.2003.199892

Keywords

Cytogenetic Biomarkers, Human Fascioliasis, Triclabendazole Treatment

Authors

First Name

Hanan

Last Name

Mahrous

MiddleName

S.

Affiliation

Human Genetic Department, Medical Research Institute, Alexandria University, Egypt

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Orcid

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First Name

Sahar

Last Name

Abou Hollo

MiddleName

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Affiliation

Parasitology Department, Medical Research Institute, Alexandria University, Egypt

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Volume

33

Article Issue

1

Related Issue

27973

Issue Date

2003-01-01

Receive Date

2021-10-17

Publish Date

2003-01-01

Page Start

105

Page End

116

Print ISSN

2357-0601

Online ISSN

2357-061X

Link

https://jhiphalexu.journals.ekb.eg/article_199892.html

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https://jhiphalexu.journals.ekb.eg/service?article_code=199892

Order

8

Type

Original Article

Type Code

511

Publication Type

Journal

Publication Title

Journal of High Institute of Public Health

Publication Link

https://jhiphalexu.journals.ekb.eg/

MainTitle

Study of Cytogenetic Biomarkers in Human Fascioliasis and Triclabendazole Treatment

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Article

Created At

22 Jan 2023