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205119

Role of Cytokines as Markers for Immunomodulation in Patients with Hepatitis C

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Last updated: 22 Jan 2023

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Abstract

In hepatitis C virus [HCV] infection, mechanisms responsible for liver cell damage are still poorly understood. Various attempts have been carried out to improve the characterization and understanding of the disease. T lymphocytes and immunoregulatory cytokines play an important role in the host response to HCV infection. In the present study soluble interleukin-2 receptor [sIL-2R] and tumor necrosis factor-alpha [TNF-a] were measured in serum by [ELISA], and alpha fetoprotein was assessed by [RIA] in twenty patients with HCV infection. In addition, ten apparently healthy subjects served as controls. The results showed increased serum level of slL-2R in patients group [783.65] U/ml than in control subject [774.19] U/ml. In the same time, the mean level of TNF-a also was significantly elevated in patients [1.51±1.01] than in control [0.39±0.07] ng/ml. Furthermore, three out of twenty HCV +ve patients had elevated serum AFP. These data indicate that the cellular immunity is obviously changed in HCV patients which is noticed by the elevation of sIL-2R and TNF-a, moreover the presence of high level of AFP in some individuals, which might reflect early detection of complications such as liver cirrhosis and hepatocellular carcinoma. 

DOI

10.21608/jhiph.2002.205119

Keywords

Cytokines, Immunomodulation, hepatitis C

Authors

First Name

Mona

Last Name

El-Sayed

MiddleName

H.

Affiliation

Department of Immunology, Medical Research Institute, Alexandria University, Egypt

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Orcid

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First Name

Ola

Last Name

Abdel Kader

MiddleName

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Affiliation

Microbiology Department, Medical Research Institute, Alexandria University, Egypt

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Volume

32

Article Issue

4

Related Issue

27972

Issue Date

2002-10-01

Receive Date

2021-11-16

Publish Date

2002-10-01

Page Start

833

Page End

846

Print ISSN

2357-0601

Online ISSN

2357-061X

Link

https://jhiphalexu.journals.ekb.eg/article_205119.html

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https://jhiphalexu.journals.ekb.eg/service?article_code=205119

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12

Type

Original Article

Type Code

511

Publication Type

Journal

Publication Title

Journal of High Institute of Public Health

Publication Link

https://jhiphalexu.journals.ekb.eg/

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Article

Created At

22 Jan 2023