Mortality statistics for adult is important for understanding the health consequences of social inequality, human behavior, biological factors, and various other forces in human populations. The present study aimed to determine the trend and pattern of adult mortality from 1996-2002, to study the mortality statistics for the leading causes of death and to estimate the life expectancy for adult. A retrospective study was conducted in health information center in Alexandria to collect data about adult mortality aged 15-59 years from the year1996 to 2002. The present study revealed that the crude death rate increased from 3.22/1000 in 1996 to 3.88/1000 in 2002. A significant increasing trend in age adjusted death rates for both males and females [F =10.01, 8.49, P <0.05],the lowest age specific death rate [ASDR] was for adult females in all age groups, while the highest one was for male population. There was a variability in ranking cause of death by years but diseases of the heart and malignancy were the first and second leading cause of death in almost all the studied years among adult aged <45 and 45 years or more, by the year 2002, the proportionate mortality rate for heart diseases was [18.1% and 22.82%] of adult deaths respectively for the both age groups, and [14.4 % &15.35%] for malignancy. The following leading causes were accident, injuries and septicemia for those aged <45 years, and cerebrovascular and chronic liver diseases for those aged 45 years or more. The proportionate mortality rate from accidents demonstrated a steady increase among young adult [from0.50% in 1996 to 15 % in 2002] Death rate from heart diseases and accidents was significantky higher among males than females. A sharp increase in the death rate from all causes was noticed among adult aged 45 years or more, from 983.37/100,000 in 1996 to 1244.5/100,000 in 2002 .There was a significant decreasing trend of life expectancy 00and this was more pronounced among male population. Better focus of the specific disease burden for adult. Health education, screening measures, are different approaches to these problems for health improvement.