Risk management program has become a necessary activity in the administration of a hospital. The present study focused on assessment of some aspects of risk management in Main University Hospital in Alexandria [MUHA], including fire prevention and control measures, performance of hospital staff in providing some patient care activities and procedures which have the potential of risk of infection, knowledge of hospital staff regarding prevention of some occupational illnesses, training programs relevant to employees safety, and the role of relevant committees in implementation of risk management activities. The study was conducted in one male general medical ward and one surgical ward in Main University Hospital in Alexandria. Six checklists were designed to collect data about fire prevention and control measures and five patient care practices. Two questionnaires were prepared for interview with nurses, housekeepers and chairmen of safety-related hospital committees namely: occupational health and safety committee, infection control committee and environment committee. The study revealed shortcomings of risk management in the MUHA , in spite of the presence of occupational health and safety committee, infection control committee and environment committee. These shortcomings includes: missing of some fire prevention control measures that were either related to design [emergency exit and fire resistant doors] or measures that are considered as being of little importance such as fire blanket, color code oxygen cylinder or label indicating oxygen in use, omission of hospital staff of some infection control measures in hand washing, urinary catheterization, cleaning, decontamination and storing process of thermometers, cleaning, and sterilization process of dressing instruments, wound dressing and pre-operative care, omission of patient's right to be informed about surgical procedure or anesthesia or any instructions before operation , lack of training programs or instructions related to employees' safety and safe work practices, lack of written protocols for safe work practices and lack of incident reporting mechanism. The study recommended that the three safety related committees should have a definite active role identified, agreed upon and totally supported by hospital administrator, developing written protocols for safe work practices and infection control practices, establishing training programs related to hospital hazards and safety measures and considering the recommended safety principles of ward design in new building or in case of extension.