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187331

Diphosphoglycerate and Phenotypic Severity of Cell Disease

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Last updated: 22 Jan 2023

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Abstract

Sickle cell disease is a hereditary blood disorder characterized by chronic manifestations of progressive organ failure. To control a disease of this type, it is important to study the factors which affect the course of the disease. Diphosphoglycerate [2,3 DPG] is the most common metabolite generated by the glycolysis. It is a potent modifier for hemoglobin function. To clarify the role of 2,3 DPG in suckling, its concentration was measured in 15 normal health individuals and in 12 sickle cell patients at steady state and during crisis. Hematological indices and partial oxygen tension [PO2] were also determined for sicklers and controls. Sickle cell patients during crisis were found to have a significant higher levels of 2,3 DPG [9.17+5.36 mold/L] [p < 0.05], and significantly low PO2 [8.41 +1.82 Kpa, p < 0.01] than controls [8.54 + 0.72 mmol/L for 2,3 DPG and 12.44 + 0.7 Kpa for PO4]. The increase in 2,3 DPG concentration during crisis may be due to its increased production via glycolysis, which in turn increased as a result of decreased oxygen tension during crisis. The increased 2,3 DPG concentration increases and stabilized the deoxygenated HbS leading to its precipitation, sickling. And hemolysis of red blood cells. In conclusion, the factors which can increase 2,3 DPG or decrease PO4 may lead to the sickling crisis and increase the phenotypic severity of the disease.

DOI

10.21608/jhiph.2004.187331

Keywords

Diphosphoglycerate, Phenotypic Severity, Cell Disease

Authors

First Name

Amina

Last Name

Gezeery

MiddleName

R.

Affiliation

Human Genetics Department, Medical Research Institute, Alexandria University, Egypt

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Orcid

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First Name

Fatima

Last Name

Abdulaban

MiddleName

S.

Affiliation

Biochemistry Department, Faculty of Science, King Saud University

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Orcid

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First Name

Mahasin

Last Name

Al-Musa

MiddleName

A.

Affiliation

Hematology Department, Riyadh and Alkarj Hospital, Riyadh, KSA

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Volume

34

Article Issue

3

Related Issue

26792

Issue Date

2004-07-01

Receive Date

2021-08-04

Publish Date

2004-07-01

Page Start

651

Page End

660

Print ISSN

2357-0601

Online ISSN

2357-061X

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https://jhiphalexu.journals.ekb.eg/article_187331.html

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https://jhiphalexu.journals.ekb.eg/service?article_code=187331

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12

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Original Article

Type Code

511

Publication Type

Journal

Publication Title

Journal of High Institute of Public Health

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https://jhiphalexu.journals.ekb.eg/

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Article

Created At

22 Jan 2023