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187325

Frequency of Arg972-IRS-1 Variant among Type I Diabetic Patients in El-Shatby Patients in El-Shatby Pediatric Hospital, Alexandria, Egypt

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Last updated: 03 Jan 2025

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Abstract

Several polymorphisms have been identified in the amino acid sequence of human insulin receptor substrate-1 [IRS-1]. The most prevalent one is glycine change to arginine at the codon 972 that was hypothesized to play a role in pancreatic ẞ-cell stimulus-coupled-insulin secretion and survival. The frequency of this variant among type I diabetic patients, their available normal sibs, and control subjects recruited from El-Shatby Pediatric Hospital, Alexandria University were studied. The result showed that the frequency of Arg972 IRS-1 variant was 14% in diabetic patients, 9.1% in normal sibs, and 4% in normal control subjects. Data revealed that Odds ratio showed that carriers of Arg972 IRS-1 variant had four times increased risk for developing the disease. In sibs, the risk is increased by three fold in carriers of this variant as compared to sibs with the wild allele. In spite being non-significant, the results of the present work suggest that Arg972 IRS-1 variant could be considered as a potential risk factor for developing type I diabetes although it was statistically non-significant, which may be attributed to the small sample size or methods of selection of cases.

DOI

10.21608/jhiph.2004.187325

Keywords

Arg972-IRS-1, Type I Diabetic, El-Shatby Pediatric Hospital, alexandria, Egypt

Authors

First Name

Sahar

Last Name

El-Shafei

MiddleName

A.

Affiliation

Human Genetics Department, Medical Research Institute, Alexandria University, Egypt

Email

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City

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Orcid

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First Name

Mervat

Last Name

El-Belvesy

MiddleName

F.

Affiliation

Human Genetics Department, Medical Research Institute, Alexandria University, Egypt

Email

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City

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Orcid

-

First Name

Maged

Last Name

Zein El-Din

MiddleName

H.

Affiliation

Human Genetics Department, Medical Research Institute, Alexandria University, Egypt

Email

-

City

-

Orcid

-

First Name

Magdy

Last Name

Abdou

MiddleName

O.

Affiliation

El-Shatby Pediatric Hospital, Alexandria University, Egypt

Email

-

City

-

Orcid

-

Volume

34

Article Issue

3

Related Issue

26792

Issue Date

2004-07-01

Receive Date

2021-08-04

Publish Date

2004-07-01

Page Start

641

Page End

650

Print ISSN

2357-0601

Online ISSN

2357-061X

Link

https://jhiphalexu.journals.ekb.eg/article_187325.html

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https://jhiphalexu.journals.ekb.eg/service?article_code=187325

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11

Type

Original Article

Type Code

511

Publication Type

Journal

Publication Title

Journal of High Institute of Public Health

Publication Link

https://jhiphalexu.journals.ekb.eg/

MainTitle

Frequency of Arg972-IRS-1 Variant among Type I Diabetic Patients in El-Shatby Patients in El-Shatby Pediatric Hospital, Alexandria, Egypt

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Article

Created At

22 Jan 2023