The present study aimed at estimating compliance with drugs among hypertensive patients [n=300] and at determining the association of compliance with blood pressure control among patients attending outpatient clinic of Abo-Qir Hospital in Alexandria. The patients were interviewed using a structured questionnaire to collect data of patients, disease, and treatment characteristics. The average compliance rate for the 2 visits was calculated using the pill count method. The compliance rate was 62.3% among compliant patients, over ninety percent [96.3%] were controlled as compared to only 41.6% among non-compliant patients [P<0.001]. Complications were significantly more prevalent among non-compliant than among compliant patients [44.2% versus 18.2%, P<0.001]. The combined effect of the six significant variables, i.e., sex, source of treatment, number of drugs, frequency of drug intake, control of hypertension, and complications of hypertension was examined by means of multiple regression analysis. The source of treatment and control of hypertension were the only significant predictors of drug compliance among hypertensive patients. Patients participation is essential to the whole process and antihypertensive drugs should be available in the clinic to make it free of charge to all patients especially poor ones.