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186159

Effects of Occupational Exposure to the Hepatotoxic Chemical Vinyl Chloride Monomer on Reduced Glutathione and its Related Enzymes

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Last updated: 22 Jan 2023

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Abstract

The effect of vinyl chloride monomer exposure on the liver of workers was studied by measuring the level of blood glutathione, glutathione-S-transferase, ỿ-glutamyl transferase, routine liver function enzymes, and alpha feto protein in the sera of eorkers. The results showed a significant decrease in the level of blood glutathione, a significant increase in the enzyme activity level of glutathione-S-transferase, and a significant increase also in the ỿ-glutamyl transferase. On the other hand, the ratio of ALT/AST= 1.07 which indicated the insignificant result of these enzymes. Of 21 workers, 14 had fatty liver infiltration, 8 of whom were also suffering from liver enlargement. Four workers had liver enlargement without fatty infiltration. The study highlights the need for vigilance in environmental monitoring and medical surveillance of workers exposed to this chemical.

DOI

10.21608/jhiph.2004.186159

Keywords

vinylchloride, glutathione, glutathione-S-transferase, ỿ-glutamyl transferase, routine liver function enzymes, alpha feto protein

Authors

First Name

Awatef

Last Name

El-Sharkawi

MiddleName

M.

Affiliation

Applied Medical Chemistry Department, Medical Research Institute, Alexandria University, Egypt

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First Name

Gamal El-Den

Last Name

Bader

MiddleName

A.

Affiliation

Internal Medicine Department, Medical Research Institute, Alexandria University, Egypt

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Volume

34

Article Issue

3

Related Issue

26792

Issue Date

2004-07-01

Receive Date

2021-07-28

Publish Date

2004-07-01

Page Start

517

Page End

528

Print ISSN

2357-0601

Online ISSN

2357-061X

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https://jhiphalexu.journals.ekb.eg/article_186159.html

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https://jhiphalexu.journals.ekb.eg/service?article_code=186159

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3

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Original Article

Type Code

511

Publication Type

Journal

Publication Title

Journal of High Institute of Public Health

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https://jhiphalexu.journals.ekb.eg/

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Article

Created At

22 Jan 2023