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194142

Influence of Decis, a Synthetic Pyrethroid Insecticide on the Immune System and Thyroid Function of Albino Rats

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Last updated: 03 Jan 2025

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Abstract

The effect of daily sublethal concentrations of decis [6.25 and 18.75 ppm] for 90 days in drinking water was investigated on the cell mediated and humoral immune responses, hormones and histopathological changes in the thyroid gland of male albino rats. Decis caused a pronounced direct suppressive effect on cellular immunity as illustrated by lymphocyte proliferation to mitogens. Also, humoral immunity as indicated by plaque forming cells [PFC] and total immunoglobulins [Ig] was significant suppressed, while both IgG [mercaptoethanol resistant antibody] and IgM [mercaptoethanol sensitive antibody] were non-significantly deceased. The suppressive effect of decis on the immune response was concentration dependent. The data also showed that plasma triiodothironine level [T] significantly increased only after 30 days of treatment with both concentrations, while thyroxine level [T4] increased at 30 and 90 days. Thyroid gland of rat treated with low level of decis showed most of acini free from the colloid with narrowing in the acini lumenae. In the case of high concentration it showed obliteration and atrophy in most acini.

DOI

10.21608/jhiph.2003.194142

Keywords

Decis, a Synthetic Pyrethroid Insecticide, the Immune System, thyroid function, albino rats

Authors

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N

Last Name

Aly

MiddleName

M.

Affiliation

Department of Pesticide Chemistry, Faculty of Agriculture, University of Alexandria, Egypt

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First Name

M

Last Name

El-Halwagy

MiddleName

S.

Affiliation

Department of Pesticide Chemistry, Faculty of Agriculture, University of Alexandria, Egypt

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Orcid

-

First Name

M

Last Name

Farid

MiddleName

S.

Affiliation

Department of Pesticide Chemistry, Faculty of Agriculture, University of Alexandria, Egypt

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Orcid

-

First Name

K

Last Name

El-Gendy

MiddleName

S.

Affiliation

Pesticide Central Lab, Agriculture Research Center, Egypt

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Volume

33

Article Issue

3

Related Issue

27358

Issue Date

2003-07-01

Receive Date

2021-09-12

Publish Date

2003-07-01

Page Start

451

Page End

464

Print ISSN

2357-0601

Online ISSN

2357-061X

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https://jhiphalexu.journals.ekb.eg/article_194142.html

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https://jhiphalexu.journals.ekb.eg/service?article_code=194142

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3

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Original Article

Type Code

511

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Journal

Publication Title

Journal of High Institute of Public Health

Publication Link

https://jhiphalexu.journals.ekb.eg/

MainTitle

Influence of Decis, a Synthetic Pyrethroid Insecticide on the Immune System and Thyroid Function of Albino Rats

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Article

Created At

22 Jan 2023