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189888

Hereditary Persistence of Fetal Hemoglobin and Genetic Heterogeneity in Alexandria, Egypt

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Last updated: 03 Jan 2025

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Abstract

Fetal hemoglobin [HbF] production in normal adults varies over a 20-fold range and is under genetic control. To estimate and assess the mode of inheritance of hereditary persistence of fetal hemoglobin [HPFH], 1009 apparently health preparatory school students were included in this study. Fetal hemoglobin and other hematological indices were determined in these subjects. Four hundred and twenty four subjects had HbF representing 42.4%. The levels of HbF ranged from 0.4%-39.5%. The frequency distribution of HbF showed 2 groups, low [≤9.5% for F1, ≤5% for F2] and high HbF group [>9.5% for F1, >5% for F2]. The hemoglobin [Hb] content showed a positive correlation with HbF level which may indicate the increased HbF in mildly anemic adults. Mathematics of population genetic on families of 66 subjects with elevated HbF showed that autosomal dominant inheritance was the possible mode in 18 families [X2 = 9.68]. In other families, the value of heritability for the first degree relatives was 91% suggesting the multifactorial inheritance. In conclusion, this form of HPFH is heterogenous and the mode of inheritance is different in different families.

DOI

10.21608/jhiph.2004.189888

Keywords

Hereditary Persistence, Fetal Hemoglobin, Genetic Heterogeneity, alexandria, Egypt

Authors

First Name

Amina

Last Name

El-Gezeery

MiddleName

R.

Affiliation

Human Genetics Department, Medical Research Institute, University of Alexandria, Egypt

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First Name

Mohamed

Last Name

Mokhtar

MiddleName

M.

Affiliation

Human Genetics Department, Medical Research Institute, University of Alexandria, Egypt

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Volume

34

Article Issue

2

Related Issue

26024

Issue Date

2004-04-01

Receive Date

2021-08-18

Publish Date

2004-04-01

Page Start

459

Page End

468

Print ISSN

2357-0601

Online ISSN

2357-061X

Link

https://jhiphalexu.journals.ekb.eg/article_189888.html

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https://jhiphalexu.journals.ekb.eg/service?article_code=189888

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13

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Original Article

Type Code

511

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Journal

Publication Title

Journal of High Institute of Public Health

Publication Link

https://jhiphalexu.journals.ekb.eg/

MainTitle

Hereditary Persistence of Fetal Hemoglobin and Genetic Heterogeneity in Alexandria, Egypt

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Article

Created At

22 Jan 2023