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189723

A Study on some Biologically and Chemically Induced Hepatic Dysfunctions

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Last updated: 03 Jan 2025

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Abstract

The present work was planned to study the influence of either hepatitis B virus [HBV] infection or occupational exposure to vinyl chloride [VC] on the detoxification capacity of the liver and on immunologic response. Also, the present study was an attempt to differentiate between biologically- and chemically-induced hepatic dysfunctions. In HBV infected patients, chronic or acute, and VC-workers, whole blood reduced glutathione [GSH] level, serum activity of ỿ-glutamyl transferase [GGT], and Glutathione-S-Transferase [GST] and liver function tests were measured. Also, T-lymphocyte count and determination of interleukin-1ẞ [IL-1ẞ] were carried out. From the present study, it was concluded that exposure to environmental factors that cause hepatic damage, either biological or chemical, affected much its detoxifying capacity through GSH and its related enzymes GGT and GST. The involvement of GSH in detoxification of reactive VC metabolites or reactive oxygen species liberated during HBV infection led to its depletion. The increase in the GST serum activity reflects its de novo synthesis and its release into circulation in response to hepatic damage. The observed change in GGT level is an adaptive mechanism in which an increase in GGT activity acts to restore GSH used in the detoxification of xenobiotic and reactive oxygen species. The results also showed that exposure to these environmental factors had its deteriorating effects on the immunoresponse which was observed by the significant reduction in the T-lymphocyte count and the significant increase in the serum level of IL-1ẞ.

DOI

10.21608/jhiph.2004.189723

Keywords

biologically, chemically, hepatic dysfunctions

Authors

First Name

Awatef

Last Name

El-Sharkawi

MiddleName

M.

Affiliation

Applied Medical Chemistry Department, Medical Research Institute, Alexandria University, Egypt

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Orcid

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First Name

Hesham

Last Name

Neanaa

MiddleName

M.

Affiliation

Hematology Diseases Department, Faculty of Medicine, Alexandria University, Egypt

Email

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City

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Orcid

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First Name

Zakia

Last Name

Abdel Rahman

MiddleName

A.

Affiliation

Immunology Department, Medical Research Institute, Alexandria University, Egypt

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Orcid

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Volume

34

Article Issue

2

Related Issue

26024

Issue Date

2004-04-01

Receive Date

2021-08-17

Publish Date

2004-04-01

Page Start

397

Page End

412

Print ISSN

2357-0601

Online ISSN

2357-061X

Link

https://jhiphalexu.journals.ekb.eg/article_189723.html

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https://jhiphalexu.journals.ekb.eg/service?article_code=189723

Order

9

Type

Original Article

Type Code

511

Publication Type

Journal

Publication Title

Journal of High Institute of Public Health

Publication Link

https://jhiphalexu.journals.ekb.eg/

MainTitle

A Study on some Biologically and Chemically Induced Hepatic Dysfunctions

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Article

Created At

22 Jan 2023