The giant leap that happened in the sports field recently is very remarkable and deserves a far greater attention. Through the physiological knowledge and information concerning sports training, it is possible now to develop sports training and ration its loads. High intensity training load is between 90 – 100% of the maximum physical ability of the athlete, reaching 180 pulses/min and above. As the training load reaches that level, it affects most of the athlete's body system, among which the cardio-pulmonary system and the immune system, specially immunoglobulins concentrations in serum. These immunoglobulins include IgA, IgM, and IgG. The present study aimed at identifying the effect of high-intensity training load on the serum concentrations of these immunoglobulins for wrestlers. Sample included (10) wrestlers purposefully chosen from “23^rd July Sports Club – Mahalla Kobra" wrestling team. The researcher used the experimental approach. Blood samples were taken before applying the training unit and (4) weeks after finishing it to evaluate the values of immunoglobulins concentrations in serum before and after application. The major finding of this research was that rational physical training that considers the correct model of loading using the high-intensity load and the correct time distribution has led to improving IgM & IgG immunoglobulins in serum, while IgA did not reach any significant level of improvement.