The aim of this study was to assess the quality of life for cancer patients undergoing chemotherapy. This study was conducted in the Oncology Unit in the Main University Hospital at Alexandria. The sample consisted of 71 cancer patients undergoing chemotherapy. The patients were selected according to the following criteria: age between 18-65 years old, both sexes with confirmed diagnosis of cancer, and treated by chemotherapy for at least one month. Data were collected using a structured interview sheet consisting of two parts. Part I included information related to socio-demographic data, disease profile, and type of chemotherapy. Part II included Ferrans and Power quality of life index for cancer patients. The finding showed that cancer patients undergoing chemotherapy had bad quality of life. Cancer and chemotherapy were adversely affecting all dimensions of quality of life. Health and functioning dimension was the worst affected whereas the family dimension was the least affected quality of life dimension. Finally, the only statistical significant correlation was found between quality life and the educational level and number of chemotherapy side effects.