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177381

Relationship of Helicobacter Pylori Infection with Different Digestive System Malignant Tumors

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Last updated: 22 Jan 2023

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Abstract

Studies have shown a close association between Helicobacter pylori infection and gastric cancer while its relationship with other digestive system tumors has not been clarified. This study evaluated whether H. pylori infection affected risk for different digestive system malignancies. Sera were tested for lgG antibodies against H. pylori using quantitative enzyme immunoassay in 222 subjects: 82 patients with digestive system malignancies including gastroduodenal, pancreatic, hepatic, and colorectal carcinomas, 82 health controls, and 58 patients with other malignancies (cancer controls). H. pylori infection was noted in 58.8% of health controls, 73.2% of patient with digestive cancer and 82.8% of cancer controls. H. pylori infection imposed 2.8 folds increased risk for colorectal carcinoma. H. pylori infection was associated with increased but non-significant risk for developing genitourinary, bone, and breast cancers. Thus large-scale epidemiological studies to confirm the association and the possible causative role of H. pylori infection in the etiopathogenesis of various digestive and non-digestive system cancers are needed to help to develop preventive measures and appropriate interventions.

DOI

10.21608/jhiph.2005.177381

Keywords

H. pylori, Gastric cancer, Hepatocellular carcinoma

Authors

First Name

Hanan

Last Name

Shatat

MiddleName

Z.

Affiliation

Tropical Health Department, High Institute of Public Health, Alexandria University, Egypt

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Orcid

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First Name

Mona

Last Name

Hashish

MiddleName

H.

Affiliation

Microbiology Department, High Institute of Public Health, Alexandria University, Egypt

Email

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City

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Orcid

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First Name

Heba

Last Name

Selim

MiddleName

S.

Affiliation

Microbiology Department, High Institute of Public Health, Alexandria University, Egypt

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Orcid

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Volume

35

Article Issue

2

Related Issue

24097

Issue Date

2005-04-01

Receive Date

2021-06-13

Publish Date

2005-04-01

Page Start

255

Page End

266

Print ISSN

2357-0601

Online ISSN

2357-061X

Link

https://jhiphalexu.journals.ekb.eg/article_177381.html

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https://jhiphalexu.journals.ekb.eg/service?article_code=177381

Order

3

Type

Original Article

Type Code

511

Publication Type

Journal

Publication Title

Journal of High Institute of Public Health

Publication Link

https://jhiphalexu.journals.ekb.eg/

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Article

Created At

22 Jan 2023