The aim of this study was to provide a possible laboratory support to health risk evaluation associated with exposure to low frequency static and alternating magnetic fields [MFs] at flux density of 3 mT, and the possible protective effect of the antioxidant drug, CoQ10. In this study, thirty male mice were exposed to a combination of static and alternating magnetic fields at flux density of 3 mT. Antioxidant drug [CoQ10] was administered at the beginning of MFs exposure. Superoxide dismutase [SOD] activity [U/mg protein] serotonin, and dopamine concentrations [μg/g brain] were determined in brain homogenates. The results indicated significant elevation in SOD activity and concentrations of serotonin and dopamine, after MFs exposure. Such alterations could not be reported after administration of the antioxidant, CoQ10. In conclusion: antioxidant drug has a beneficial effect on brain tissues against MF exposure.