Intestinal schistosomiasis is one of the most wide spread parasitic disease which is caused by digenetic trematodes of the parasite schistosoma mansoni. Chemotherapy with orally administered antischistosomal drugs remains the best method to care for people infected by the parasites. However, this approach is rather expensive, an alternative method is to destroy the intermediate host with molluscicidal agents. The molluscicidal activity of Euphorbia schimperiana [Euphorbiaceae] had been determined. Many experiments were done to investigate the characterization of Euphorbia schimperiana extract as antischistosomal drug and morphological changes of the treated worms were noted and compared with the normal ones. Reduction in worm burden, oogram changes, and reduction of eggs in tissues were the three criteria considered for the assessment of antischistosomal activity.