Objective: To determine the demographic characteristics and history of risky exposures among acute leukaemic children in Alexandria. Subjects and Methods: A descriptive cross-sectional study started Nov.2004 for one year duration, included 163 cases [all acute leukaemic cases attended in and out-patient of Alexandria University Paediatric Hospital, either newly diagnosed or for follow up, and who are below the age of 15]. Questionnaire sheet was completed by interview with patient's mothers included demographic data, Known environmental risk factors, and maternal reproductive history. Medical records of cases were reviewed as well. Results: Most cases [84.7%] suffer B-lineage acute lymphoblastic type, T-lineage, and acute non-lymphoblastic types and counts for 13.5% and 1.8%, respectively. Commonest age group for disease onset was [3-5 years = 31.3%], mean age of onset [5.1±2.6] years. 58.3% of cases were males, males to females ration was 1.4:1. 69.3% of cases are from rural areas. 65.6% are of low socioeconomic level. Most encountered risky exposures were recurrent intake of drugs, exposure to X-ray, insecticides, electro-magnetic fields, repeated infections, close parents consanguinity, and family history of cancer. The percent of these factors were [48.5%, 13.5%, 26.3%, 13.5%, 35.6%, 23.3% and 16.5%], respectively. Conclusion: The study is an update of acute childhood leukaemia demographic characteristics, counts for cases and their clinical types, and mentions of the current risky exposures. It document that many factors are implicated in the etiology of this relatively not uncommon disease.