Considerable effort has been applied to identifying antioxidants in foods and the mechanisms behind their antioxidative activity in vivo. Therefore, the effect of systemic food antioxidants [AO] addition on hypercholestrolemic rats has been investigated and the lipoprotein profile in rats induced with cholesterol in diet was examined. The overall data gave the assumption that vitamin C and carotenes that particularly extracted from parsley curly are most important food fragments of active nutrients as Hypocholesterolemic agent besides the unique role of soyproteins. The other most important fact revealed in this study is that dietary therapy needs a long time to be of real efficiency and might not present any remarkable response in the short run. As a matter of fact, the admensration of this dietary therapy, based on the continual addition of some main antioxidants, caused a partial healthier cure. The blood analysis as well as liver morphology, function and histopathology were used in evaluating the final health impact of that systemic antioxidant application. However, the liver, as the main lipogenic organ in the body, was positively affected by specific antioxidant supplementation, most probably soyprotein, carotenoids, and vitamin C. This organ undergoes a great change in mass or size, enzymatic actively, and tissues histological change with changing food additives of those hypercholesterolemic rats.  Evidence of that the cholesterolemia is a major great pathological disorder negatively affect most organs especially liver is strong. In consequences, the AO in their best formulation should be deeply incorporated in food pattern in order to protect against a variety of diseases. The form of seimodified food is a practical and effective one. In general, a simple correlation between normalized serum lipoprotein and organ longevity has been noticed. Normal effective liver, but not enlarged organ, means more actively one for overall body homeostasis. Liver homeostatic function is strongly conjugated to the balanced diet and dietetics, as the liver is the main body organ that deals with nutritional homeostasis. Here, the relatively high content of vitamin C and carotenes in parsley played a sort of synergistic role with soyprotein. Further research is required to determine the mechanism by which some protein in the presence of some specific nutrients or medical substance accelerate the low density lipoprotein [LDL] and very low density lipoprotein [VLDL] uptake and secretion by liver.