With the ultimate aim of assessment of the suitability of the Membrane Bioreactor [MBR] technology for wastewater reclamation in Saudi Arabia, this study conducted investigations on a pilot scale MBR plant, receiving domestic wastewater, located in Al-Khomra, Jeddah for three months. The MBR units realized excellent organics, nutrients, and pathogen removal performances irrespective of the applied mixed liquor suspended solids [MLSS] concentrations [10, 15, and 20 g/L] and hydraulic retention times, HRT [8, 6 and 3 hrs.] without encoun-tering severe membrane fouling. During the course of investigation, the influent Bio-Chemical Oxygen Demand [BOD] [198-253 mg/L], Chemical Oxygen Demand [COD] [445-575 mg/L], Total Kjeldhal Nitrogen [TKN] [18-26 mg/L], and Total phosphorous [TP] [8.6-13.6 mg/L] were removed with efficiencies varying between the ranges of 95-98%, 90-95%, 99-100%, and 40-50%, respectively, and the best quality effluent achieved during this investigation convincingly satisfied the quality requirements for reuse in unrestricted irrigation in the country. A 2.1 to 3.1 log removal of fecal coliforms and a 5 to 6 log removal of total coliforms were also accomplished. In addition to the confirmation of the technical viability, simultaneous comprehensive assessment and analytical approaches also revealed the economic feasibility along with the eco-friendliness of the process.