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22546

Angiotensinogen Gene (M235T) Variant and Pre-Eclampsia in Egyptian Pregnant Women

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Last updated: 03 Jan 2025

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Abstract

Association between the angiotensinogen gene (M235T) and pre-eclampsia has been confirmed in recent studies. Pre-eclampsia is a complication of pregnancy characterized by increased vascular resistance, higher blood pressure, proteinuria and oedema that appear in the second and third trimester of pregnancy. This study aimed at investigating the relationship between M235T gene polymorphism and pregnant women with different forms of pre-eclampsia. One hundred and fifteen pre-eclamptic women and 100 normal control group were recruited and evaluated for the frequency of M235T mutation using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). A positive association was found between maternal age over 35 years (OR= 6.67; CI: 2.09-23.59), previous family history of hypertension (OR= 3.01; CI: 1.18-7.66), previous pre-eclampsia (OR= 7.44; CI: 2.47-22.42), history of reproductive losses (OR= 53.98; CI: 3.23-90.88), fetal anomalies (OR= 8.4; CI: 1.06-180.33), and pre-eclampsia. The frequency of heterozygous carriers of M235T mutation in pre-eclampsia (19.1%) was higher than that in control (14%) but the difference was statistically non-significant. Also, the frequency of M235T mutation was higher in mild pre-eclampsia women (63.6%) compared to women with severe pre-eclampsia (36.4%), however this was statistically non-significant. This study revealed that the frequency of M235T mutation was higher within women with mild pre-eclampsia.

DOI

10.21608/jhiph.2007.22546

Keywords

Angiotensinogen Gene (M235T) Variant, Pre-eclampsia, Pregnant women, Egypt

Authors

First Name

Nargues

Last Name

Hassanein

MiddleName

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Affiliation

Department of Human Genetics Medical Research Institute, Alexandria University, Alexandria, Egypt

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City

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Orcid

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First Name

Mohamed

Last Name

Mokhtar

MiddleName

M.

Affiliation

Department of Human Genetics Medical Research Institute, Alexandria University, Alexandria, Egypt

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Orcid

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Volume

37

Article Issue

3

Related Issue

4204

Issue Date

2007-07-01

Receive Date

2018-12-21

Publish Date

2007-07-01

Page Start

655

Page End

669

Print ISSN

2357-0601

Online ISSN

2357-061X

Article File

JHIPH_Volume 37_Issue 3_Pages 655-669.pdf

PDF . 229.1kB

Link

https://jhiphalexu.journals.ekb.eg/article_22546.html

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https://jhiphalexu.journals.ekb.eg/service?article_code=22546

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6

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Original Article

Type Code

511

Publication Type

Journal

Publication Title

Journal of High Institute of Public Health

Publication Link

https://jhiphalexu.journals.ekb.eg/

MainTitle

Angiotensinogen Gene (M235T) Variant and Pre-Eclampsia in Egyptian Pregnant Women

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Article

Created At

22 Jan 2023