Structure empowerment enhances nurses' power to accomplish their work within hospitals. Access to these empowering structures is influenced by formal power system within the hospital which refers to job characteristics   that contribute to job recognition. So, job characteristics  are the core to reach to excellent quality patient care and to achieve organizational outcomes. The purpose of this study is to determine the relationship between staff nurses' perception of  structural empowerment and their job characteristics. The data were collected from 182 staff nurses working  at MansouraSpecializedMedicalHospital. Two tools were employed for data collection. The first tool is structure job empowerment  questionnaire which is divided into two parts: a) Conditions for Work Effectiveness Questionnaire (CWEQ) and b) Organizational Description Opinionnaire (ODO). The second tool is Staff Nurses Job Characteristics Index Questionnaire (SNJCIQ). The results concluded that there are a strong and significant relationship between staff nurses' perception of structure empowerment and  their job characteristics. This study recommended that application of job characteristics model nutrients to empower staff nurses, and improve the quality of nursing care.