In pesticides and fertilizer formulation and packaging processes, workers may be exposed to toluene, benzene, xylene, carbon monoxide emissions as well as noise and reduced illumination during milling, mixing, loading, packaging and storage operations. Occupational hazards are associated with exposure to mixtures containing high proportions of active ingredients, and exposure to carriers/fillers and additives. The present study was designed to assess occupational exposure to chemicals, physical, hazards and safety practice in the pesticides and fertilizers packing industry. It was conducted in pesticide and fertilizer packing industry. Occupational exposure to organic solvents as toluene, benzene, xylene and carbon Monoxide as well as noise and illumination levels were carried out using calibrated instruments. Safety practice was done using safety questionnaire. Analyzed data revealed high significance increase levels of toluene, benzene, xylene, and carbon Monoxide as well as in the levels of noise and illumination in fertilizers and pesticides packing departments in comparison with administrative area. Nevertheless, the conditions of many of the safety practice are not satisfactory while the others are satisfactory and adequate. It was concluded that there are great needs for improvement, including identifying and controlling the hazards. providing information, training, monitoring and also legislative requirements that need to be met.