In the last 10 to 15 years, the healthcare industry has clearly shifted its focus from implementing financial information systems to clinical information systems in order to improve outcomes, reduce medication errors, increase healthcare efficiency, and eliminate unnecessary costs. This paper describes the experience of one of the leading health organization in Saudi Arabia in implementing a Computerized Physician Order Entry (CPOE) solution to meet patient safety measures. The realized benefits gained from the CPOE implementation are explained and the lessons learned are discussed.  The paper also explains the main Critical Success Factors (CSF) used to increase the likelihood of project success.