This study aimed at assessing the knowledge of women about pregnancy changes, self care during it, and development of an educational booklet based on the results of the assessment. The study was conducted at antenatal clinic at El-Shateby University Hospital. From the previous setting, a purposive sample consisting of 200 women was selected. A Structured Questionnaire sheet was developed and used to find out the knowledge and practice of the study sample about pregnancy changes and self care during it. The results found that the majority of women lack basic knowledge about pregnancy changes and self care during pregnancy.