Background: Nephrotic syndrome is primarily a pediatric disease that is associated with high relapse rate. The nature of the disease and the side effects of medical treatments result in a great threat to children, families and society. Objective: to assess the level of self- care practices of school- aged children with Nephrotic syndrome and to identify the predictors of low self-carefuel shop Methods: A cross-sectional descriptive study was done to100 school-aged children with Nephrotic syndrome selected from the urology outpatient clinic at Mansoura university children's hospitals. Self-care practices of school age children with Nephrotic syndrome questionnaire (SCSCNSQ) Arabic version was developed by the researchers. Demographic, clinical, and self care requisites data were collected and analyzed using SPSS version 11. Results: most of the studied children had low level of self-care (self care deficit). Frequency of re-hospitalization, parents' socioeconomic standard, education and occupation were significant predictors for low self care. Regression analysis revealed that the Morerisky predictors in decreasing order are fathers' education, socioeconomic standard and frequency of hospital admission. Conclusion: Self-care level of nephrotic syndrome children should be assessed and educational training program should be provided to caregivers of children with risky predictors of low self care to improve disease outcome and minimize re-hospitalization.