Background: School age children are the parents, workers, leaders, and decision makers of tomorrow & their futuer success depends in good measure on acheivment of their educational goal today. Communicable diseases (CD) are the leading cause of killer of children and young adults. It accounts for over half the total burden of disease in poor countries with high mortality rates. In particular, they cause over 13 million deaths each year, and account for one out of every two children's deaths. In addition, a small number of infectious diseases are responsible for 90% of deaths: pneumonia, AIDS, diarrhea, tuberculosis, malaria, and measles Person with infectious diseases may exhibit a broad spectrum of disease that rang from inapparent infection to severe and fatal disease and increase spread of infection to large number of people thus increase economic burden. Objective: study is to assess knowledge and practices of school personnel towards communicable diseases among school students. Methods: Study subjects were distributed among the following schools: Elekhssass, Shallaby, Eltagrebia, Elfoly, Elmontazha, Elsalah, Houda Shaghrawy, Saaed Zaglol,Taric Ebn Ziaed, Othman Ebn A fan, Elsaedia and Omar Ebn Elkhtab. In El-Minia city 2008; subjects of this study are consist of a sample size which inclued  525 primary school personnel (471 teachers, 42 workers and 12 school nurses),the schools selected randomly after excluding of  private schools and schools with special needs. The tools used included tow types; a)-structured assessment questionnaire, and b)-observational checklist. Results: There are statistical significant differences were found among awareness of school personnel about infection and  (CD). Statistically significant differences were found among awareness of school personnel about measures used to prevent spread of infection among students. There are statistical significant differences were found among school personnel related to the sources of getting information. There are statistical significant differences were found between school teachers and nurses when they find communicable diseases among students. There are statistical significant differences were found between school teachers and nurses toward health education. Conclusion and Recommendations: All school personnel weren't completely oriented to (CD) that affect their students, lack of inservice training program for the school personnel, and unavailability of health insurance guide books, and all school workers had not any protective clothes during work time. All school districts should provide initial inservices training program about (CD) for all staff, and an annual update for the all.