Background: Bronchial asthma is one of the most prevalent chronic lung diseases among children in Saudi Arabia. Morbidity and mortality associated with asthma has continued to increase despite advances in treatment and management. Improve maternal knowledge about asthma and Increase their  coping abilities through the empowerment strategies  will be expected to have a good impact on interventions of their asthmatic children, decrease the prevalence of complications, increase compliance with management as well as improve prognosis of the disease process and general health of the asthmatic children. Objective: Was to assess maternal knowledge, practice and coping abilities with asthma and to evaluate the impacts of the empowerment strategies on mothers' knowledge, practice and coping abilities. The study was conducted at  pediatric department of Al- Dawadmi General Hospital, Al Dawadmi Governorate, Kingdom of Saudi Arabia. Methods: A sample of 50 asthmatic children mothers was included in the study. Interviewing questionnaire sheet and coping inventory scale were used to collect the required data (Pre and post empowerment strategies test were done). Data were collected in 4 phases (initial, developmental, implementation and evaluation). Results: The results revealed that most of asthmatic children were males (60%), 80% of them had positive family history and all of them (100%) were exposed to asthma triggers before asthma attacks. In total, 10%, 26% of mothers used nebulizer and O₂ mask correctly pre the intervention compared with 80% of them post intervention for both items. Only 12% of mothers avoided exposure to asthma triggers pre the intervention which changed significantly post the intervention where we found 86% of them avoided exposure to triggers. The minority of mothers (6%) had high coping abilities with asthma pre the empowerment strategies, which changed significantly post the empowerment strategies where we found 70% of them had high coping abilities. The results also demonstrated significant change in the disease prognosis and in the asthmatic children general health due to the impacts of the empowerment strategies. Conclusion: It was concluded that asthma is a common health issues affecting children with sometimes life threatening consequences that need continuous nursing intervention to improve disease prognosis, reduce severity of outcomes, reduce complications and improve maternal coping abilities.