Serum levels of Angiopoietin-2 (Ang-2) and C-reactive protein (CRP) were measured in 50 patients with chronic myeloid leukemia (CML) (30 patients in chronic phase (group A) and 20 patients in advanced phase (group B)) and 15 healthy age and sex matched subjects as a control group, to investigate their relation to different phases of the disease. Serum levels of both Ang-2 and CRP were significantly higher (p<0.05) in patients group compared to controls, and in advanced stage compared to chronic phase. Furthermore a significant positive correlation was detected between Ang-2 and CRP in the whole patients group which could support the hypothesis that CRP might play a role in modulating angiogenesis. The present data suggest that both Ang-2 and CRP could play a role in the leukemic process. Understanding their roles may help in follow-up care and in designing new therapeutic strategies for CML. Furthermore the role of CRP in modulating angiogenesis should not be underestimated.