Background: Air pollution index is not applied in Egypt up till now. Objectives: This study is a trial to apply the concept of air pollution index  (API) to assess the air quality and its health concerns at one of the heavy traffic streets in Alexandria; Egypt. Methods: This was a case study that was conducted over one year, the setting of which was one of the heavy traffic streets. The total suspended particulate matter (TSP) was sampled using "High Volume Air Sampler," for 24 hours/day with simultaneous measurement of local meteorological parameters. Results: The total suspended particulates exceeded the National Standards during 78 measurement days out of 84 (92.9%). Application of air pollution index revealed that 19% of the measurement days were of good air quality, 28.6% harmful for sensitive groups, 20.2% unhealthful for the public, 15.5% very unhealthy, and 16.7% hazardous to the public. Conclusion: Traffic concentrations of TSP at the streets under study exceeded the Egyptian National Standards during all weekdays and all months throughout the year. The air quality during the working days (Sunday to Thursday) was unhealthy to the general population. The API was the highest during Spring Season. Application of an air pollution control strategy with generalization and communication of air pollution index in Egypt were recommended.