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19987

Measles and Rubella Vaccine Antibody Levels in Children with Acute Lymphoblastic Leukemia Following Chemotherapy

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Last updated: 03 Jan 2025

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Abstract

Background: Children in remission from acute lymphoblastic leukemia (ALL) have a high prevalence of immune system defects; one of them is the decrease of vaccine-induced antibody seropositivity rates. This antibody deficiency may place children with ALL at risk for the development of vaccine- preventable diseases, even after completion of chemotherapy, and they could function as a reservoir for additional spread of these diseases in the population. The aim of the present study was the assessment of the levels of vaccine- induced antibodies against measles and rubella viruses in ALL children following chemotherapy. Methods: Antibody levels against measles and rubella vaccine viruses were evaluated by ELISA technique in 96 children with ALL after completion of chemotherapy, in addition to 30 healthy children (non cancer controls of matched age and sex). Results: All healthy children were seropositive for measles and rubella antibodies.On the other hand, out of 96 children who received chemotherapy, only 19 (19.8%) were seropositive for measles antibodies, while 70 (72.9%) were seropositive for rubella antibodies. Most of measles seropositive cases (57.9%) had low levels of measles antibodies while among control group most children (56.7%) had high levels of measles antibodies. Similarly among children who received chemotherapy, most of the seropositive cases (45.7%) had low levels of rubella antibodies, while among control group, most of children (36.6%) had high levels of rubella antibodies. Seropositivity rate of measles was found to be related to the age at diagnosis and disease duration, while that of rubella was found to be related to the disease duration only. Conclusion and recommendations: Most of children who have been treated with chemotherapy for ALL had lost measles antibodies and to less extent rubella antibodies. Among seropositive cases, levels of measles and rubella antibodies are low following treatment with chemotherapy compared to levels among normal controls. Therefore, revaccination of children with ALL following completion of chemotherapeutic treatment against measles and rubella is recommended.

DOI

10.21608/jhiph.2013.19987

Keywords

Acute lymphoblastic leukemia, measles, rubella, vaccine

Authors

First Name

Heba

Last Name

Selim

MiddleName

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Affiliation

Microbiology Department, High Institute of Public Health, Alexandria University, Alexandria, Egypt

Email

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City

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Orcid

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First Name

Soraya

Last Name

El shazly

MiddleName

-

Affiliation

Microbiology Department, High Institute of Public Health, Alexandria University, Alexandria, Egypt

Email

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City

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Orcid

-

First Name

Mostafa

Last Name

Salama

MiddleName

-

Affiliation

Pediatric Department, Faculty of Medicine, Alexandria University, Alexandria, Egypt

Email

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City

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Orcid

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First Name

Reham

Last Name

Abdolmonem

MiddleName

-

Affiliation

Microbiology Department, High Institute of Public Health, Alexandria University, Alexandria, Egypt

Email

-

City

-

Orcid

-

Volume

43

Article Issue

1

Related Issue

4038

Issue Date

2013-04-01

Receive Date

2018-11-28

Publish Date

2013-04-01

Page Start

36

Page End

48

Print ISSN

2357-0601

Online ISSN

2357-061X

Article File

JHIPH_Volume 43_Issue 1_Pages 36-48.pdf

PDF . 80.7kB

Link

https://jhiphalexu.journals.ekb.eg/article_19987.html

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https://jhiphalexu.journals.ekb.eg/service?article_code=19987

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Original Article

Type Code

511

Publication Type

Journal

Publication Title

Journal of High Institute of Public Health

Publication Link

https://jhiphalexu.journals.ekb.eg/

MainTitle

Measles and Rubella Vaccine Antibody Levels in Children with Acute Lymphoblastic Leukemia Following Chemotherapy

Details

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Article

Created At

22 Jan 2023