Introduction: Melkersson–Rosenthal syndrome is a rare condition that is of unknown or unclear etiology , neuro_mucutanous
characterized by a triad of orofacial edema, facial paralysis, and a fissured tongue. In this article we present a rare case that
shows the absence of granulomatous histological features which is a usual findings.
Case report: A 17-year-old Sudanese boy presented to our clinic at Sharq Alnil Hospital complaining of upper lip and facial
swellings of one month duration. Clinical examinations revealed severe lip and facial edema, 'fissured tongue and unilateral
facial palsy. Histopathological investigation did not reveal any granulomatous formation. The patient was treated successfully
with systemic steroids.
Conclusion: Although Melkersson–Rosenthal syndrome may present without granulomatous histopathlogical features it
still respond to systemic steroid in its management. Evaluation and treatment of Melkersson-Rosenthal syndrome require
multidisciplinary approach by an allergologist-immunologist, neurologist, dentist, maxillofacial surgeon and histopathologist.
Regular follow-up of these patients is necessary.