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232722

Synthesis and characterization of Erythromycin loaded PLGA and PCL microspheres: Antimicrobial application

Article

Last updated: 23 Dec 2024

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Subjects

-

Tags

Human Microbial Interactions
Medical Microbiology

Abstract

We present in this work the preparation of several formulations based on biocompatible biodegradable polymers: polycaprolactone (PCL) and poly (lactic-co-glycolic) acid (PLGA) loaded with Erythromycin(ERYT) antibiotic. These biocompatible materials were used to pre-pare microspheres with and without immobilized ERYT via the simple evaporation method and simple emulsion. The particle size was determined by scanning electron microscopy and the absence of the interaction with ERYT was confirmed via X-ray diffraction and infrared spectroscopy. The release kinetics of ERYT were studied and then, ERYT loaded PCL and PLGA blends microspheres were used for the inhibition of gram-positive S. aureus strain. The microbial activity was carried out by the agar diffusion disc method. The results show that PCL/PLGA blend and only PCL inhibited the bacteria strain by ERYT present in kinetic aliquots with the complementary effect of the polymers. A numerical model was proposed for modeling the kinetics reported in our study.

DOI

10.21608/mb.2022.122642.1051

Keywords

Biodegradable polymers, Erythromycin, microspheres, release kinetics, Antibacterial activity

Authors

First Name

Lamia

Last Name

Bennabi

MiddleName

-

Affiliation

Laboratory of Organic Chemistry, Physics, and Macromolecules (LCOPM), University of Sidi Bel Abbes, Sidi Bel Abbes, Algeria.

Email

lamia.bennabi@univ-tiaret.dz

City

-

Orcid

-

First Name

Ilham

Last Name

Abedlmalek

MiddleName

-

Affiliation

Department of Chemistry, Faculty of Matter Sciences, University of Tiaret, Tiaret, Algeria.

Email

-

City

-

Orcid

-

First Name

Abedelkader

Last Name

Ammari

MiddleName

-

Affiliation

Laboratory of Micro and Nanophysics (LaMiN), National Polytechnic School of Oran (ENPO), Oran, Algeria.

Email

-

City

-

Orcid

-

First Name

Khaldia

Last Name

Sediri

MiddleName

-

Affiliation

Laboratory of Applied Chemistry (LAC), University of Ain Temouchent, Ain Temouchent, Algeria.

Email

-

City

-

Orcid

-

First Name

Fatima

Last Name

Bennabi

MiddleName

-

Affiliation

Department of Medicine, University of Saad Dahlb, Blida, Algeria.

Email

-

City

-

Orcid

-

First Name

Kaddour

Last Name

Guemra

MiddleName

-

Affiliation

Laboratory of Organic Chemistry, Physics, and Macromolecules (LCOPM), University of Sidi Bel Abbes, Sidi Bel Abbes, Algeria.

Email

-

City

-

Orcid

-

Volume

6

Article Issue

2

Related Issue

29387

Issue Date

2021-12-01

Receive Date

2022-02-18

Publish Date

2022-04-22

Page Start

43

Page End

52

Print ISSN

2357-0326

Online ISSN

2357-0334

Article File

MB_Volume 6_Issue 2_Pages 43-52.pdf

PDF . 704.1kB

Link

https://mb.journals.ekb.eg/article_232722.html

Detail API

https://mb.journals.ekb.eg/service?article_code=232722

Order

6

Type

Original Article

Type Code

502

Publication Type

Journal

Publication Title

Microbial Biosystems

Publication Link

https://mb.journals.ekb.eg/

MainTitle

Synthesis and characterization of Erythromycin loaded PLGA and PCL microspheres: Antimicrobial application

Details

Type

Article

Created At

22 Jan 2023