The first record of Chaetomium iranianum (Ascomycota, Chaetomiaceae) for the Egyptian and African fungi is reported here. The species was found during an extensive taxonomic and ecological revision of genus Chaetomium supported by Science and Development Technology Fund (STDF) in Egypt. Chaetomium iranianum identified phenotypically and was subjected to sequencing for confirmation of phenotypic identification. The internal transcribed spacer (ITS) 1–5.8 s – ITS2 rDNA sequences obtained were compared with those deposited in the GenBank Database and registered with accession number MF787598 in the NCBI Database. We provide an updated full description and illustration of the species.