Gastric cancer is one of the prevalent malignant tumors all over the
world. In the current study we aimed at elucidating a possible correlation
between LncRNA-HOTAIR polymorphisms rs7958904 G>C and
rs874945 G>A and risk of developing gastric cancer in Egyptian patients.
Blood samples were collected from controls and patients. We performed
real-time polymerase chain reaction (RT-PCR) for genotyping of the two
variant alleles at the SNPs sites of HOTAIR gene in all subjects. As regard
rs7958904 SNP, there was statistically significant higher mutant genotype
CC and Mutant C allele among gastric cancer patients and as regard
rs874945 SNP, there was statistically significant higher mutant genotype
AA and Mutant A allele among gastric cancer patients. As regard
rs874945 SNP, the mutant genotype AA and the Mutant A allele were
statistically significantly higher in Positive H. pylori patients than negative
H. pylori patients. In Conclusion, the mutant genotypes (CC and AA) of
rs7958904and rs874945 SNPs of LncRNA-HOTAIR gene predominate in
gastric cancer patients that would displayed their impact in increasing the
risk of developing gastric cancer in Egyptian patients, while the wild
genotypes (GG and GG) predominate in controls which support our
hypothesis.