End-stage renal disease is associated with the inflammatory state
characterized by infiltrating macrophages/lymphocytes, a major
source of chemokines. The aim of this study was to determine the
association of CCR2 G190A polymorphism in patients with chronic
renal failure (CRF) requiring hemodialysis. Seventy CRF patients and
thirty healthy controls were enrolled in the current study; PCR-RFLP
technique was used to assess the gene frequencies of CCR2 G190A.
The results of the present study showed that there was a significant
difference in the genotype and allele frequency distribution of CCR2
G190A in CRF patients and control subjects. A significant association
was found between CCR2 G190A and CRF risk, especially, the AA
genotype (OR= 2.5, 95% CI=0.26-23.66) and A allele (OR=2.9, 95%
CI=1.14-7.3). The polymorphism was significantly associated with the
presence of diabetes mellitus. From this study, it could be concluded
that, a significant association was found between the AA genotype of
CCR2 G190A polymorphism and CRF. Other chemokine
polymorphisms in renal pathologies have to be further investigated
with larger population based studies.