Sandy soil is a poor soil which has low of organic matter and nutrition. soil productivity had constrained, but also the environmental deterioration and economic losses were getting worse and worse. Two field experiments were conducted over two consecutive winter seasons 2019-2020 and 2020-2021 in sandy soil, of Agriculture Station ARC at Ismalia governorate, Egypt. The experiment was split plot design with three replicates. The obtained results cleared that the compost and biofertilizers application combined with 75 kg fed-1 N + 150 kg fed-1 P2O5 + 50 kg fed-1 K2O increased N, P and K concentrations and uptake in seeds of quinoa plants. The interaction between biofertilizers and compost combined with different rates of mineral fertilizers was significant for plant length (cm), weight of seeds /plant, weight of 1000 grains and weight of grains yield (ton fed-1), while the No. of branches was not significant. The highest values of the protein (%), protein yield (kg fed-1), carbohydrates (%), oil (%) and chlorophyll (mg g-1 f.w.) contents in quinoa were obtained with compost combined with mineral fertilizers at rate (75 N + 150 P2O5 + 50 K2O kg fed-1) as compared with other treatments. It could be recommended the use of integrated biofertilizers or compost combined with 75% of the recommended mineral fertilizers for production of quinoa plant grown on sandy soils.