The critical situation about water resources in Egypt forces the state to increase its uses from non-conventional water resources (reuse of wastewater and desalination). Wastewater reuse represent a potential source for a round 8 Billion Cubic Meters (BCM) /year. The micropollutant and the sophisticated specification hinder the usage of wastewater. Advanced oxidation process represents a new potential way for improving the effluent of Waste Water Treatment Plants (WWTPs). In this work the discharge of three WWTPs (Arab-Abosaaed station located in Helwan-Cairo, El-Berka station located in El-Salam city-Cairo and Balaqs station located in Shubra El-Kheima-Cairo) were investigated and treated. The investigation illustrated that El Berka WWTP is the most vulnerable WWTP this why its effluent was used to conduct further treatment on it. The three WWTPs are appropriate for use according to Egyptian law 48/1982 and the uses quality for treated wastewater are fitted with Class D and Class C Code 501/2015 specification. Effluent from the three-treatment plant is unsuitable for uses according to Class A and B. Hydrogen peroxide, Fenton, and photo-Fenton were used as advanced oxidants to improve the effluent quality. All the oxidants used has been successfully implemented to achieve 100% WWQI for different reuse purposes. However, the cost benefit of using hydrogen peroxide is more favorable as it cheaper. Further comparison between the scaleup option, hydrogen peroxide is more applicable to be scaled up and moreover, it could be nationalized as a strategic industry.