The current research aims to reveal the relationship between social isolation and the concept of the self and their relationship to drug addiction, to identify the drugs and their various side effects and how dangerous they are for the individual and society, and to verify the presence of differences between males and females in their appetite for drug addiction, as the study sample included (100) a single, divided equally by (50) items as a sample for males, and (50) items as a sample for females from users from different groups of society in different regions, so that this sample represents as much as possible the research community, The researchers used the social survey method based on the measure of social isolation and the scale of the concept of the self, as methods that serve the purpose of the research. The researchers have reached in this research some of the most important results: the presence of a strong correlation statistically significant between the psychological factors (social isolation) and (the concept of self) With its dimensions (self-awareness, physical self-concept, mathematical self-concept, family self-concept, self-concept of emotional stability, self-concept of problem solving) for the male and female samples, there are no statistically significant differences between the mean scores of the study sample (popular / high-end neighborhood) of all dimensions and totals of the measure of social isolation and the concept of self. The research also recommended a set of recommendations, the most important of which is the importance of the necessity of developing a strategic plan that includes providing educational and educational courses and programs that serve young people (males and females) in order to reduce the addiction to narcotic drugs.