In this work ,nanohydroxyapatite was synthesized by two methods, the first method is the natural method which is synthesized from tilapia fish bone, The second method is the chemical method via wet method as model adsorbent for the removal of manganese which often occurs as geogenic contaminants in untreated surface water, ground water and drinking water. The prepared samples were characterized by Energy dispersive X-ray spectroscopy (EDX), X-ray diffraction (XRD), Fourier Transformation infrared (FTIR) spectroscopy, (BET) Brunauer Emmett Teller surface area device, scanning electron microscope(SEM), The Bruker Senterra spectrometer (Raman) and The Inductively coupled plasma mass (ICP–MASS7700). The characterization study demonstrated a substantial improvement in several adsorptive parameters of natural (nHAPn) and chemical nanohydroxyapatite (nHAPE) like surface area and surface morphology, where the surface area of nHAPE and nHAPn were observed (78.019 m²/g) and (26.028 m²/g), respectively.The particles size of nHAPE and nHAPn were (169.9-251.5) nm, (471.5-514.6), nm respectively.Effects of pH, initial concentration, mass of the adsorbent and the contact time on the adsorption capacity were studied. The results showed that the best pH for adsorption was at pH=7, optimum dose of nHAPE and nHAPn at 0.3 g, initial concentration 25 ppm and contact time at 60 min. The maximum removals efficiency of nHAPE and nHAPn were (99.59 %) and (83.73%) for manganese. The maximum adsorption capacity of nHAPE and nHAPn were (4.22mg/g) and (3.2mg/g) for manganese.