The study aimed to identify the role of management information systems, especially in hospitals, in improving environmental performance. A field study on the Cairo Heart Institute Hospital, Researchers in this study relied on an inductive approach: based on data, statistics and historical facts. The research is based on the study of management information systems and their role in improving the environmental performance of hospitals based on data and statistics from sources Such as books, periodicals, publications, scientific journals, and internet conferences. The researchers also used the descriptive and analytical approach in defining the research problem represented in highlighting management information systems and their role in improving environmental performance in hospitals, and to achieve the goal of the research, a sample of 300 individuals was selected. This study relied on the method of investigation to collect the necessary primary data. Direct and directed, the survey list was presented to a number of managers at the National Heart Institute, as well as some academics specialized in the field of management information systems in Egyptian universities and research centers, in order to verify the extent of the content's validity of the measures used in the list. In light of the results of the study, the most important of which is that there is a statistically significant relationship between the availability of software and the improvement of the environmental performance of the Heart Institute Hospital in Cairo. There is a statistically significant relationship between the management information systems and the improvement of the environmental performance of the Cairo Heart Institute Hospital. It has been possible to reach through a proposed framework the most important recommendations, including the need to establish a central information system at the level of the National Heart Institute hospital in cooperation between the Ministry of Health and Population and the specialized information bodies that includes a group of experts and consultants working on planning and policy-making and providing the hospital management with accurate, clear and sufficient data and information. Which helps them to make the right decisions and then provide a good health service. Establishing a special department for medical quality at the National Heart Institute Hospital that includes a group of capable and specialized expertise in the field of quality management at the Institute.