Background: Bronchial asthma is a chronic inflammatory disorder that is related with hyperresponsiveness of the airways and leads to repeated episodes of wheezing, dyspnea, chest tightness, and cough, which is often reversible, either spontaneously or after treatment Severe, steroid-resistant asthma is clinically and economically important, patients with this disease experience more frequent exacerbations of asthma, and are more likely to be hospitalized, and have a poorer quality of life. The association between vitamin D deficiency and asthma and allergies has recently increased significantly. Epidemiologic data in most of the reported studies suggest that low serum vitamin D (defined as circulating levels of 25(OH)D of ,30 ng/mL) in children with asthma is associated with more symptoms, exacerbations, reduced lung function, increased medication usage, and severe disease.
The aim of the current study is to evaluate the effect of vitamin D3 in patients with resistant asthma among childhood and elderly asthmatics.
Methods: This study includes 60 Resistant asthmatic subjects including 30 patients with serum 1.25 OH Vitamin D3 deficiency, who will be followed up after VITAMIN D3 supplementation therapy for three months and will be compared with 30 resistant asthmatic subjects with normal serum 1.25 OH Vitamin D3.
Results: during the study period 1000 IU Vitamin D3 were supplemented to childhood asthmatics and 2000 IU Vitamin D3 were supplemented to elderly resistant asthmatics and Vitamin D3 was measured at the start and the end of the study.
Conclusions: improvement in the pulmonary functions (FEV1, FVC, FEF) especially with those of vitamin D3 deficiency after vitamin D supplementation for 12 weeks.
Recommendation: The study recommend that Measurement of vitamin D must be a routine step in resistant asthma among childhood and elderly resistant asthmatics, Vitamin D supplementation during childhood and adolescence, in adequate doses could be among the national nutritional priorities.