The presence of pollutants in the lakes considers the most common problem facing consumers. So, the aim of this study was to monitor the physiochemical, bacteriological properties of Qarun lake. It is a closed saline lake in the northern part of El-Fayoum Depression (Middle Egypt) at the margin of the Great Western Desert. During the 20^th century, lake water salinity has increased strongly as a result of high evaporation rate. Also fish productivity decreased strongly. It receives agricultural and domestic non-treated drainage waters, which are also used for aquaculture in Qarun area. The study aimed to know the state of the lake and monitored the effect of agricultural drainages and domestic on the concentration of pollutants. The Physiochemical, bacteriological and some heavy metals monitored during the summer of 2017 to compare it with the previous results of the lake. The study proved that the lake suffering pollution by heavy metals as Cd (0.0034mg/l), Zn (1.091mg/l) at Al-Bats drain, NH₃ (0.58 mg/l),PO₄^-3(1.38mg/l),COD (292mg/l) and BOD (71mg/l) at Al-Wadi drain. Therefore, it is necessary to put an environmental policy to control this pollution.