This study aims to identify the nature of the mental flexibility to cancer patients affected by psychological pressures resulting from the disease and affect the behavior of the patient in the various aspects of his life, in order to adapt to patients with the disease. Which leads us to study how to improve the level of mental flexibility in cancer patients, the study of the psychological and social consequences of cancer treatment. To achieve this goal, the researcher hired a sample of the actual study of cancer tumors Aswan center totaling patients (140) patients, aged between 30 years and over 50 years. The researcher apply a treatment program that includes psychological flexibility measure them and the sample survey for three consecutive months. They selected 60 patients who received the lowest scores when answering vertebrae and dimensions of psychological flexibility used measure to represent the true and final study sample (experimental sample), then patients were divided into two groups, experimental group applied by the program and the number (30) patients and a control group of (30) patients, has addressed the data obtained by using the individual differences between the averages and test T and standard deviation: There are statistically significant differences at the level (0.05) between the measurement pre and post experimental group to gauge the psychological flexibility. There were no statistically significant differences at the level (0.05) between the pre and post measurement of the control group to measure the psychological flexibility. There are statistically significant differences at the level (0.05) between the experimental group and the control group on the scale of mental flexibility in posttest performance dimensions. There were no statistically significant differences at the level (0.05) between the average of the experimental group on the psychological measure of flexibility in the post test and iterative program.